Job ID: R0035251 | Laboratory Research | Full Time | Charlottesville, VA
The Radiochemistry Core within the School of Medicine seeks a Radiochemist (Lab Specialist or Lab Specialist – Intermediate) to support expansion of the capabilities to provide investigators with PET radiotracers intended for human use. This requires meticulous recordkeeping and scrupulous laboratory performance to satisfy FDA regulations for maintaining a cGMP environment.

This Role Is Responsible for:
Maintaining and operating the Radiochemistry Core laboratory to comport with USP <823> guidelines under the supervision of the Core Director. The candidate will assist the Director in synthesizing batches of radiopharmaceuticals intended for human use, perform quality control testing necessary for final product release, and document all corresponding data in a clear and concise format.

Additional Job Responsibilities:
  • Conduct manual and automated radiochemical syntheses of both established and research radiopharmaceuticals.
  • Operate the following laboratory equipment: HPLC, GC, automated radiochemical synthesizer, endotoxin PTS and other equipment necessary for production.
  • Maintain analytical and other laboratory equipment.
  • Maintain maintenance logs (daily, weekly, monthly) of laboratory equipment.
  • Generate and execute standard operating procedures for general lab upkeep (including, but not limited to, cleaning, inventory, chemical compounding, quality control, chemical entity specifications and reagent receipt logs).
  • Attend weekly or biweekly lab meetings. Prepare and organize data for presentation. Attend lab visits or scientific meetings with the Director.
  • Perform manual radiochemical syntheses in a shielded hotcell and maintain equipment (hot plates, oil baths, vacuum pumps, gas supply) within. Perform independently or assist the Director in automated radiochemical syntheses. This will involve assembling final product vials using aseptic technique, assembling and/or loading cassettes onto the automated synthesis platform, and operating and maintaining a semi-prep HPLC system.
  • Operate analytical instruments, such as HPLC and GC, to support release of final product for use. Perform day-of-use calibration standards. Calibrate, operate and maintain radioTLC for radiochemical purity. Operate and maintain an endotoxin PTS. Perform, monitor and document final product sterility. Bubble point testing of product solution filters. Silica TLC for chemical purity testing. Conduct all human radiopharmaceutical production operations with aseptic technique. Perform work in both Biosafety cabinets and ISO-5 hood.
  • Organized and meticulous in recordkeeping.
  • Strong English verbal and written communication skills.
  • Sufficient interpersonal skills to collaborate with a variety of highly motivated researchers from various disciplines.

Minimum Requirements Laboratory Specialist:
  • Education: Bachelor's degree. Preference for bachelor's degree in biomedical/biological sciences or similar.
  • Experience: 3 years of experience in basic science research. 6 years of experience accepted in lieu of degree.

Minimum Requirements Laboratory Specialist – Intermediate:
  • Education: Bachelor's degree. Preference for bachelor's degree in biomedical/biological sciences or similar.
  • Experience: 6 years of experience in a lab technician role in basic science research. Master's degree may substitute for required experience. 9 years of experience accepted in lieu of degree.

This position can spend extensive periods of time standing and squatting while conducting experiments or caring for animals. Also requires keyboarding and other bench work and animal procedures requiring fine finger manipulation.

This is a restricted position; continuation is dependent on funding and satisfactory performance.

The position will remain active until filled.

The successful candidates will pass a criminal background check and pre-employment health screening.

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Please visit the UVA COVID-19 Job Requirements and Guidelines webpage prior to applying for current information regarding vaccination requirements and guidelines for employment at UVA.




Charlottesville, VA
Charlottesville, VA 22903

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