Lab and Research Technician
Job ID: R0039339 | Laboratory Research | Full Time | Charlottesville, VA
The University of Virginia (UVA) seeks a Lab and Research Technician in the laboratory of Bon Trinh, PhD, tenure-track Assistant Professor of Pathology.

The broad areas of interest in Dr. Trinh's lab include gene regulation by RNAs and proteins, modulation of gene-specific chromatin architecture, blood development, cancer and genetic diseases, and therapeutic development. His lab employs a multidisciplinary approach, comprising biochemistry and cellular biology, as well as global transcriptomic, epigenomic, and 3D chromatin structure analyses, using normal and cancer cells and mouse models.

Research in the Trinh lab centers on protein- and RNA- mediated gene regulation via modulating chromatin architecture in the development and function of immune cells, particularly myeloid cells, a critical component of the body defense against infections, and how abnormalities in this regulation contribute to failure in myeloid cell maturation, resulting in acute myeloid leukemia. The lab also investigates this molecular coordination in drug resistance and immune cell-cancer cell communications within the tumor microenvironment. The aims are to provide critical mechanistic insights into normal and malignant hematopoiesis, and to establish certain protein-RNA hubs as actionable therapeutic targets and molecular markers, contributing to the emerging field of precision medicine.

The successful candidate will join a multidisciplinary research group that performs experimental and computational methods. Candidates with skills in molecular biology, cellular biology, and mouse models are highly desired. Junior candidates without these skills but with a strong work ethic and learning spirit are also considered. Computational and statistical skills are a plus but not required.

  • Perform routine tasks assigned by supervisor and develop skills with some degree of independence when following established protocols and procedures.
  • Assume routine to moderately complex technical support for research projects.
  • Collect specimens; set up and perform experiments (some with repetitive nature); and prepare culture media, chemicals, reagents, and solutions as instructed.
  • At direction of principal investigator or senior staff, perform biological, hematological, and/or bioinformatic analyses.
  • May learn and perform some surgical procedures and treatment operations on small lab animals.
  • Prepare support materials; compare and assist with analyses of data and write reports.
  • Assist with literature reviews.
  • Operate, adjust, and maintain specific scientific apparatuses and instruments.
  • Order lab supplies and maintain inventory. Record accurate information and logs of experimental data.
  • Keep informed of new lab techniques.
  • Provide routine, technical, and administrative support to research projects.
  • May provide logistical support to the study.
  • In addition to the above job responsibilities, other duties may be assigned.

  • Education: High school diploma or equivalent.
  • Experience: At least 1 year of lab experience, which may include student experience. Bachelor's degree will be considered in lieu of experience.
  • Licensure: None.

This position can spend extensive periods of time standing and squatting while conducting experiments or caring for animals. Also requires keyboarding and other bench work and animal procedures requiring fine finger manipulation.

The University of Virginia, established in 1819 by Thomas Jefferson, is recognized annually as one of the nation's top public institutions and the University of Virginia Medical Center is listed as one of America's Top Hospitals. Charlottesville is located in Central Virginia, 110 miles from Washington, DC, and 70 miles from Richmond. It has been recognized as one of America's top cities to live, raise a family, conduct business, and retire. It has also been recognized as one of America's Top Green Cities. Located near the Blue Ridge Mountains, it is popular with outdoor enthusiasts with extensive opportunity for hiking, running, cycling, tennis, golf, and skiing.

The University of Virginia, including the UVA Health System and the University Physicians Group, are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person's perspective and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity or expression, marital status, national or ethnic origin, political affiliation, race, religion, sex (including pregnancy), sexual orientation, veteran status, and family medical or genetic information.

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Charlottesville, VA
Charlottesville, VA 22903

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