Lab Specialist in Cardiovascular Functional Genomics - Center for Public Health Genomics
Job ID: R0037206 | Laboratory Research | Full Time | Charlottesville, VA
The Miller Laboratory at the University of Virginia (www.millerlab.org) seeks a highly motivated Laboratory Specialist with a background in the life sciences (e.g., genetics, molecular biology, cell biology, developmental biology, engineering, or similar fields) to investigate the genomic and epigenomic basis of inherited vascular diseases and cardiomyopathies. Our group has recently investigated the causal mechanisms of genetic loci associated with coronary artery disease and related cardiovascular diseases with a focus on understanding the regulation and targeting of mural cell signaling pathways. These efforts are expected to reveal the "hidden risk" for complex diseases for more precise prediction and early-stage prevention.

The candidate will be primarily involved in performing routine experiments following established procedures and protocols, such as cell culture (monolayer or organoids), and histology/immunohistochemistry/immunofluorescence and molecular biology (e.g., cloning, PCR, qPCR). The candidate will be expected to generate and assist in the generation and analysis of omics data sets, including, but not restricted to, single-cell (e.g., snRNA-seq, snATAC-seq) and spatial genomics data sets from both normal and diseased environments. The candidate will be expected to maintain an inventory of working reagents, supplies and consumables and to routinely check/calibrate laboratory equipment and instruments. The candidate will be expected to work largely independently and under supervision on protocol optimization, data collection, and analysis and to work with staff, postdocs, and students on multiple team projects in parallel. The candidate will benefit from a highly interactive and inclusive environment in the Center for Public Health Genomics with strong collaborations with nearby labs and members of the Robert M. Berne Cardiovascular Research Center.

Qualifications:
  • Bachelor's degree in the life sciences or a related field by appointment start date with a minimum of three years of research experience.
  • A master's or equivalent degree or experience in a related field will also be considered.
  • Excellent written and oral communication skills are required, as are excellent organization and management skills.
  • Experience in human genetics, molecular biology, engineering, or similar field is preferred.
  • Knowledge of statistical genetics and next generation sequencing analyses is preferred.

This is a restricted position contingent upon the continuation of funding and biannual performance review.

The University will perform background checks on all new hires prior to employment. A completed pre-employment health screen is required for this position prior to employment.

PHYSICAL DEMANDS
This position can spend extensive periods of time standing and squatting while conducting experiments or caring for animals. Also requires keyboarding and other bench work and animal procedures requiring fine finger manipulation.



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Charlottesville, VA
Charlottesville, VA 22903

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