The University of Virginia (UVA) seeks a Lab Specialist – Intermediate position in the laboratory of Bon Trinh, PhD, tenure-track Assistant Professor of Pathology.
The broad areas of interest in Dr. Trinh's lab include gene regulation by RNAs and proteins, modulation of gene-specific chromatin architecture, blood development, cancer and genetic diseases, and therapeutic development. His lab employs a multidisciplinary approach, comprising biochemistry and cellular biology, as well as global transcriptomic, epigenomic, and 3D chromatin structure analyses, using normal and cancer cells and mouse models.
Research in the Trinh lab centers on protein- and RNA- mediated gene regulation via modulating chromatin architecture in development of immune cells, particularly myeloid cells, a critical component of the body defense against infections, and how abnormalities in this regulation contribute to failure in myeloid cell maturation, resulting in acute myeloid leukemia. The lab also investigates this molecular coordination in drug resistance and immune cell-cancer cell communications within the tumor microenvironment. The aims are to provide critical mechanistic insights into normal and malignant hematopoiesis, and to establish certain protein-RNA hubs as actionable therapeutic targets and molecular markers, contributing to the emerging field of precision medicine.
The successful candidate will join a multidisciplinary research group that perform experimental and computational methods. Candidates with strong skills in molecular biology, cellular biology, and mouse models are highly desired. Computational and statistical skills are a plus but not required. Candidates are also expected to have experience in lab management and good communication skills.
Engage in laboratory research by performing complex lab and research-related tasks.
Develop, design, and conduct increasingly complex research projects.
Perform complex tasks independently; adapt methods and procedures to meet the needs of research.
Help the principal investigator coordinate research projects, performing experimental procedures, collecting information and data, and preparing tissues and specimens for procedures.
Participate in formulating research methods, suggesting options for improving quality and recommending solutions.
Participate in computer database design, utilization, and research/data analyses. Suggest future improvements to data measurement.
Oversee day-to-day operation of projects. Schedule and maintain records of equipment/facilities.
Train users in equipment operation and research techniques and explain and demonstrate technology and equipment capabilities, operations, limitations, and outcomes.
Work independently on collection of data and analyze research results.
Confer with PIs in developing plans for research projects and discuss the interpretation of results and the preparation of scientific manuscripts for publication.
Supervise research support personnel and manage budgets.
In addition to the above job responsibilities, other duties may be assigned.
Education: Bachelor's degree.
Experience: 6 years of experience in a lab technician role. Master's degree may substitute for required experience. 9 years of experience accepted in lieu of degree.
This position can spend extensive periods of time standing and squatting while conducting experiments or caring for animals. Also requires keyboarding and other bench work and animal procedures requiring fine finger manipulation.
This is a restricted position; continuation is dependent on funding and satisfactory performance.
The University of Virginia, established in 1819 by Thomas Jefferson, is recognized annually as one of the nation's top public institutions and the University of Virginia Medical Center is listed as one of America's Top Hospitals. Charlottesville is located in Central Virginia, 110 miles from Washington, DC, and 70 miles from Richmond. It has been recognized as one of America's top cities to live, raise a family, conduct business, and retire. It has also been recognized as one of America's Top Green Cities. Located near the Blue Ridge Mountains, it is popular with outdoor enthusiasts with extensive opportunity for hiking, running, cycling, tennis, golf, and skiing.
The University of Virginia, including the UVA Health System and the University Physicians Group, are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person's perspectives and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity or expression, marital status, national or ethnic origin, political affiliation, race, religion, sex (including pregnancy), sexual orientation, veteran status, and family medical or genetic information.
UVA assists spouses and partners seeking employment in the Charlottesville area. To learn more, please visit https://dualcareer.virginia.edu/
For more information about UVA and the Charlottesville community, please see http://www.virginia.edu/life/charlottesville
COVID Vaccination Requirement and Guidelines
Please visit the UVA COVID-19 Job Requirements and Guidelines webpage prior to applying for current information regarding vaccination requirements and guidelines for employment at UVA.